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KMID : 0370220230670030189
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Yakhak Hoeji
2023 Volume.67 No. 3 p.189 ~ p.196
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Analysis of Socioeconomic Indirect Cost of Premature Death in Patients with HER2-positive Metastatic Breast Cancer (MBC) using Nationwide Claims Data
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Ko Hwa-Yeon
Choi Ah-Hyung
Hong Bin
Bae Ki-Hwan
Oh In-Sun
Park Sun-Kyeong
Park Yeon-Hee
Shin Ju-Young
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Abstract
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The premature deaths caused by human epidermal growth factor receptor-2 protein (HER2) positive metastaticbreast cancer (MBC) among working age groups result in significant socioeconomic losses. This study aims to quantifythe socioeconomic burden of disease in female patients and provide evidence that can inform healthcare policy decisions.
We identified deaths from HER2-positive MBC over the period from 2007 to 2021, using nationwide claims data of SouthKorea. Then, we estimated years of potential life lost (YPLL), years of potential productivity lost (YPPLL), and cost ofproductivity loss (CPL) to quantify socioeconomic burden of the disease. During the period from 2011 to 2020, a total of3,576 patients died from HER2-positive MBC. The total YPLL over the period of 10 years from 2011 to 2020 was128,605 years, corresponding to an average of approximately 36.0 years per deceased patient. The total YPPLL during thesame period was 55,608 years, corresponding to an average of approximately 15.6 years per deceased patient. Additionally,total CPL of approximately 310 million won per deceased patient was incurred. All three disease burden indicators werehighest among the age group of 40 to 54 years, which are individuals in their most productive time of life.
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KEYWORD
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Cost of productivity loss, HER2-positive metastatic breast cancer, Human capital approach, Years of potential life lost, Years of potential productivity life lost
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